This Brief is to be used in conjunction with the Quality of Research for Development in the CGIAR Context (QoR4D) on the operationalization of the framework for assessment of One CGIAR research initiative proposals. The aim of QoR4D is to have broad applicability across CGIAR and go beyond the specific application of assessing research initiatives. Criteria are framed to ensure research initiative developers put an inquiry into understanding the context, anticipating the needs of end-users and opportunities that might emerge, and building a package of partnerships and activities required to reach high-level outcomes and impacts. The criteria also have been designed as a means of providing feedback for improving individual proposals and their implementation and to provide advice to System Council.